In PD/DLB [36] and tg models [33], previous studies have shown that α-synuclein accumulates not only in neurons but also in glial cells Moreover, we have shown α-synuclein transmits from neuron to glial cells [37], that this is enhanced by TLR2 overexpression (Additional file 1: Figure S2) and that this might result in neuro-inflammation in models of synucleinopathy [33]. This evidence concerns the gene TLR2 and Parkinson disease.