The neocortex of PD/DLB patients and α-Syn tg mice were double-immunolabelled against TLR2 and various cellular markers, such as NeuN (neuron, Fig. 1a and d), GFAP (astrocyte, Fig. 1b and e), and Iba-1 (microglia, Fig. 1c and f). This evidence concerns the gene TLR2 and Lewy body dementia.