To test this hypothesis, we administrated anti-TLR2 antibody (T2.5, a TLR2 functional blocking antibody) to high expresser α-Syn-tg (Line 61), which mimics neuropathological and functional aspects of PD/DLB including neuroinflammation and increased TLR2 expression (Fig. 1d-f). This evidence concerns the gene TLR2 and Parkinson disease.