A woman, who fulfilled Chompret’s Revised criteria for germline TP53 genetic testing for Li-Fraumeni syndrome (LFS) [15] due to the history of multiple malignancies, however was not referred for a clinical genetics assessment and was found to have a pathogenic variant in TP53 (c.473G > A; p.Arg158His) consistent with LFS. Here, TP53 is linked to Li-Fraumeni syndrome.