MAPK6 and neoplasm: The functional annotations and pathway analyses showed that the seven hubgenes genes were involved in many critical tumor-related biological functions and metabolic pathways, such as “epithelial cell proliferation”, “AMPK signaling pathway”, “FoxO signaling pathway”, “Estrogen signaling pathway”, “MAPK6/MAPK4 signaling” and “MAPK family signaling cascades”.