Here, we identified seven circRNA–miRNA–mRNA axes (hsa_circRNA_100291/miR-1276/FOXO1, hsa_circRNA_100291/miR-583/ESR1, hsa_circRNA_100291/miR-583/JUN, hsa_circRNA_100291/miR-583/AR, hsa_circRNA_104515/miR-877-5p/AR, hsa_circRNA_104515/miR-142-5p/MYC, hsa_circRNA_104515/miR-142-5p/MYCN, hsa_circRNA_104515/miR-142-5p/IGF1 and hsa_circRNA_104515/miR-142-5p/CD34), indicating competitive regulatory relationships of hsa_circRNA_100291 and hsa_circRNA_104515 with the seven genes in HCC. This evidence concerns the gene ESR1 and hepatocellular carcinoma.