Moreover, Enhancer of zeste homolog 2 (EZH2) was found to be involved in loss of TSSC3 expression [32] and the expression of TSSC3 could be altered by 5-Aza-CdR (a DNA methyltransferase inhibitor) treatment in osteosarcoma cells [39]. The gene discussed is EZH2; the disease is osteosarcoma.