ESR1 and neoplasm: The FAO signature was significantly higher in ER-positive, compared to negative tumours (Figs 2a, b, Wilcoxon rank sum test p < 0.01); grade 1 compared to 3 (Figs 2c, d, Wilcoxon rank sum test p < 0.01); and luminal compared to basal/HER2-enriched molecular subtypes (Figs 2e, f, g, Wilcoxon rank sum test p < 0.01).