CD9 silencing in three CD133+ glioblastoma cell lines triggered amelioration of cancer cell proliferation, survival, invasion, and self-renewal ability through impacting activation patterns of the Akt, MapK, and Stat3 signaling transducers, in which the signaling pathways are mainly involved in cell survival functions, which in turn resulted in expression alternations of CD133, nestin, and SOX2 [45]. Here, PROM1 is linked to glioblastoma.