More recent studies in large multinational cohorts of Central European origin support that alleles HLA-DQA1*01:01, HLA-DQB1*05:03 and DQB1*06:01 and their associated haplotypes are strong susceptibility factors to achalasia [8], and their distributions among these populations influence the prevalence of achalasia in Europe. The gene discussed is HLA-DQA1; the disease is Achalasia.