In Mexican admixed populations, different studies have reported high frequencies of HLA class II alleles, including HLA-DRB1*04:04, DRB1*14:02, and DRB1*01:02 in rheumatoid arthritis (RA); DRB1*03:01 in systemic lupus erythematosus (SLE); and DRB1*11:04 in systemic sclerosis (SSc), that predispose the recipients to different autoimmune disorders [57–59]. The gene discussed is HLA-DRB1; the disease is autoimmune disease.