As can be seen in Fig 2B, the expression of AHR in the most primitive CML cells was found to be close to that seen in controls, whereas leukemic CD34+ cells exhibited low levels of AHR, with persistent statistically significant difference as compared to controls (p = 0.0003, Fig 2B). Here, CD34 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.