As can be seen in Fig 4, after 4 days of culture in the presence of SR1, there was a major increase of CML progenitors recovered from these cultures (x3 fold) This effect was further increased when the cells cultured for 7 days and 14 days (x10 fold) suggesting a cumulative effect of AHR inhibition during this period. The gene discussed is AHR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.