As can be seen in Fig 3, when CML cells obtained at diagnosis either as non-purified PBMC (Fig 3A) or purified CD34+ cells (Fig 3B) there was a massive expansion of leukemic cells after 7 days of culture in the presence of SR1 (Fig 3A). Here, CD34 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.