STAT3 and neoplasm: We also evaluated nuclear STAT3 expression by multivariate analysis, which revealed it to be significantly associated with cancer-specific survival after adjustment for pathological stage, lymph node involvement, lymphovascular invasion, and tumor grade (hazard ratio = 2.136, 95% confidence interval = 1.009–4.767, p = 0.047, Tables 2 and 3, multivariate model 2).