According to the human GWAS databases grasp.nhlbi.nih.gov and www.ebi.ac.uk/gwas/, SNP variants in Acot11 are significantly associated with (among others) the rate of cognitive decline in Alzheimer disease, behavioral disinhibition, cardiovascular disease, and triglyceride levels. The gene discussed is ACOT11; the disease is early-onset autosomal dominant Alzheimer disease.