In addition, SAHA epigenetically regulates the miR‐17‐92 cluster and MCM7 to enhance the expression of MICA in hepatoma cells.12 In CAL27 and SCC25 cells, SAHA treatment significantly increases the expression of tumor suppressors miR‐107 and miR‐138 but decreases the expression of oncogenes PKCε, HIF1β, CDK6, and RhoC.13 Wolf et al14 demonstrated that SAHA specifically inhibited the expression of xCT‐transporter to produce tumor cell stress, allowing xCT equilibration and leading to a normalized tumor microenvironment. This evidence concerns the gene RHOC and neoplasm.