MMP overexpression promoted cancer metastasis by breaking down the extracellular microenvironment,39 and Nanog is a stem cell transcription factor that is crucial for malignant transformation and progression.40 Our study also indicated that SAHA or/and MG132 suppressed the migration and invasion of neuroblastoma cells by decreasing the expression of MMP‐2, MMP‐9, and Nanog in SH‐SY5Y cells. This evidence concerns the gene NANOG and neuroblastoma.