Our study comes with the significant advantages that our group of patients with CBS was double the size of that used in previous pilot studies; the depth of assessments including thorough clinical and neurophysiological evaluation, and multimodal tau and amyloid-β molecular and volumetric and microstructural assessment of molecular and structural pathology in vivo; the comparisons with large sized cohorts of healthy individuals, but also patients with MCI due to AD, and in one case the concurrent tau and amyloid-β PET imaging and histopathological examination of brain biopsy. This evidence concerns the gene MAPT and Alzheimer disease.