Five pathways emerged as being particularly variable in tumor tissues (i.e., average biological variance in malignant samples above 0.02): “Fanconi Anemia Pathway,” “Meiosis,” “Meiotic synapsis,” “Regulation of cell cycle progression by plk3,” and “Role of brca1, brca2, and atr in cancer susceptibility.” These pathways are involved in DNA damage response and include proteins such as serine/threonine protein kinase ataxia telangiectasia and Rad3-related protein (ATR) and the cohesion complex. The gene discussed is PLK3; the disease is Fanconi anemia.