As especially the PD1-PD-L1 axis appears to be a central process across cancer entities, it is not surprising that the antibodies nivolumab, pembrolizumab (both anti-PD1) or atezolizumab, avelumab and durvalumab (anti-PD-L1) are approved for a growing number of indications based on efficacy (10). This evidence concerns the gene CD274 and cancer.