When individual responses were compared, contacts of Buruli ulcer patients produced significantly higher IFN-γ responses compared with those of patients for ATp (median 3,416 vs 449 pg/ml), Ksalt (4,611 vs 521 pg/ml), ACP2 (3,794 vs 319 pg/ml), KS C (3,945 vs 618 pg/ml), DH (median 4,596 vs 671 pg/ml), ER (5,024 vs 3,010 pg/ml), KR B (5,261 vs 1,004 pg/ml), Atac2 (4,900 vs 1,215 pg/ml) (P < 0.05). Here, ACP2 is linked to Buruli ulcer disease.