Interestingly, statistical studies have established associations between age-related hearing loss and genes linked to reactive oxygen species (ROS) detoxification, such as arylamine N-acetyl-transferase 2 and glutathione S-transferase [4, 5], strongly confirming an essential role of mitochondria and oxidative stress in age-related hearing loss. The gene discussed is HPGDS; the disease is presbycusis.