TALDO1 and hepatocellular carcinoma: Evidence supporting the importance of the pentose phosphate pathway can also be found in TALDO1–/– mice developed by inactivation of the Taldo1 genomic locus.55 These are very sensitive to APAP treatment and exhibit a loss of mitochondrial membrane potential, reduced ATP/ADP ratio, and reduced β-catenin phosphorylation and spontaneously develop hepatocellular carcinomas.