WNT5A and chronic obstructive pulmonary disease: The non-canonical Wnt5a that is associated with aging (43), carcinogenesis (30), as well as with activation of pro-inflammatory processes during M1 phenotype macrophage differentiation and pro-inflammatory cytokine production (63–65) was up-regulated upon CS exposure and was found in megavesicles/oncosomes of COPD patients.