This concept is supported by the observation that bevacizumab, an anti-VEGF antibody used to treat patients with various types of cancer or diabetic proliferative retinopathy causes hypertension and proteinuria mimicking the effect of sFlt-1 (Eremina et al., 2008; Muller-Deile and Schiffer, 2011; Hayman et al., 2014). This evidence concerns the gene VEGFA and hypertensive disorder.