SYNPO and preeclampsia: In this context podocyturia (loss of podocytes in the urine), along shedding of slit diaphragm proteins such as nephrin, podocin, synaptopodin and podocalyxin were noticed in preeclampsia, and even precede the typical clinical features of preeclampsia by several weeks (Garovic et al., 2007a,b, 2013; Aita et al., 2009; Zhao et al., 2009, 2011; Facca et al., 2012; Jim et al., 2012; Kelder et al., 2012; Wang et al., 2012; Chen et al., 2013; Son et al., 2013).