EDN1 and preeclampsia: One of the main mediators of the adverse renal consequences of preeclampsia is ET-1 (Taylor et al., 1990; Mastrogiannis et al., 1991; Benigni et al., 1992; Granger et al., 2006; George and Granger, 2011, 2012; George et al., 2012; Verdonk et al., 2015; Davenport et al., 2016; Saleh et al., 2016; Bakrania et al., 2017).