Macugen was designed to target vascular endothelial growth factor (VEGF) for the treatment of age-related macular degeneration (AMD), however did not show superior therapeutic effect than VEGF-specific monoclonal antibodies (Ng et al., 2006; Mousa and Mousa, 2010; Ferrara and Adamis, 2016). Here, VEGFA is linked to age-related macular degeneration.