Lipoprotein(a) is an independent risk factor for CVD events, especially myocardial infarction (Waldeyer et al., 2017), potentially through accelerated atherosclerosis as a result of intimal deposition and/or prothrombotic or anti-fibrinolytic effect as apolipoprotein (a) possesses structural homology with plasminogen and plasmin. The gene discussed is PLG; the disease is atherosclerosis.