Indeed, significant amounts of cholesterol are present in drusen and subretinal drusenoid deposits (Curcio et al., 2001, 2005; Oak et al., 2014), the two hallmarks of AMD, and AMD risk factors include variants of several cholesterol-related genes (ABCA1, APOE, CETP, LIPC, LPL, LRP6, and VLDLR) (Miller, 2013). This evidence concerns the gene APOE and age-related macular degeneration.