TNF and Crohn disease: These research efforts were vital in directing the attention of the pharmaceutical industry to initial anti-TNF approaches, which eventually resulted in clinical trials that were successfully performed for a variety of chronic inflammatory diseases, including rheumatoid arthritis (Elliott et al., 1993), psoriasis, psoriatic arthritis, Crohn’s disease, juvenile idiopathic arthritis, spondyloarthritis, and Behçet’s disease (Sfikakis, 2010).