For example, Weir et al. (2012) reported increased SIRT3 mRNA levels in human post-mortem midfrontal and temporal neocortical tissues from AD patients (Weir et al., 2012), while in contrast, Yin et al. (2018) reported decreased SIRT3 mRNA and protein levels in human AD post-mortem cortical regions (Supplementary Table S1). Here, SIRT3 is linked to Alzheimer disease.