SIRT3 and brain infarction: For example, cerebellar granule neurons overexpressing SIRT3 displayed enhanced neuronal death in response to low potassium ion treatment (Pfister et al., 2008), and SIRT3-KO mice displayed smaller brain infarct volumes than wild type mice following reversible MCAO (Novgorodov et al., 2016), and Verma et al. (2018) also recently reported ischemia/reperfusion damage to be reduced in SIRT3-KO mice.