SIRT3 and stroke disorder: These results do not necessarily contradict the anti-oxidant or anti-apoptotic capacity of SIRT3, as the severity or type of stroke challenge could differentially activate ROS-dependent or ceramide-dependent cell death cascades (Novgorodov and Gudz, 2011; Mencarelli and Martinez-Martinez, 2013), but they do highlight the possibility that SIRT3 may differentially regulate stroke-related outcomes in tissue- or context-dependent manners (Dittenhafer-Reed et al., 2015).