Collectively, these studies suggest that the endogenous functions of SIRT3 may indeed play a protective role in PD pathogenesis, and suggest SIRT3 may represent a therapeutic target for PD translational development, particularly since hyperacetylation of MnSODK68 has been observed in post-mortem midbrain tissues from PD patients (Shi et al., 2017). Here, SIRT3 is linked to Parkinson disease.