CLU and Alzheimer disease: Using these cells, a protective role for clusterin was found in a human neuronal model of the amyloid cascade, which supports the importance of clusterin in amyloid-dependent AD pathogenesis previously established in post-mortem tissue and animal models (May et al., 1990; DeMattos et al., 2002; Thambisetty et al., 2010; Narayan et al., 2011).