Of note, NAC treatment did not significantly affect the percentage of SENP3-deficient CD45.2+ Foxp3– T cells, IFN-γ expression and suppressive function of SENP3-deficient Treg cells in tumors (Fig. 7j–m), indicating that treatment with NAC perturbs tumor-infiltrating Treg cell stability and function in an SENP3-dependent manner, thereby contributing to the antitumor effect of NAC. Here, IFNG is linked to neoplasm.