Regarding the samples’ melanoma cells, a high quotient of cytoplasmic/nuclear Twist (groups were: low [cytoplasmic-to-nuclear Twist ratio ≤ 2] and high [cytoplasmic-to-nuclear Twist ratio > 2]) was associated with a higher risk for death in comparison with low proportion of cytoplasmic Twist (age-adjusted HR 2.3, 95%-CI [1.2;4.3]; p = 0.013). This evidence concerns the gene TWIST1 and melanoma.