In the melanoma patient samples, high CEACAM1 expression did not correlate with low IGFBP7 expression which might be due to the fact that the IGFBP7 promotor is silenced (methylated) in most melanoma with BRAF mutation which comprise roughly half of all cases of melanoma27 in which low CEACAM1 expression would still not lead to an increase in IGFBP7. The gene discussed is BRAF; the disease is melanoma.