The data presented here together with the previous study28 certainly argue for further studies to carefully evaluate the role of LXN in melanoma in more detail, especially as of the three markers (IGFBP7, LXN and cyt./nuc.TWIST) which significantly contributed to prognosis in the selected model LXN would be the easiest to interfere with e.g. by pharmacological inhibition. This evidence concerns the gene LXN and melanoma.