In particular, analysis of available RNA-seq data revealed a significant upregulation of alpha-FETOPROTEIN (AFP; a HCC marker when expressed in adult livers), JAG1, NOTCH3, NOTCH4, SOX9, VIM (progenitor markers) and CD24 (a HCC prognosis marker; Fig. 5b). The gene discussed is SOX9; the disease is hepatocellular carcinoma.