For the several genes found overexpressed and with hypermethylated CGIs in the H+E+ patient subset, such as WT1, DLK1, TP73, EEF1A2, IGF1R, DKK1, SPOCK1, ITPKA, HOXA3, NOX4, FZD10, VASH2, GATA2, SOX8, their upregulation in HCC samples is coherent with their reported function as oncogenes in cancer. The gene discussed is DKK1; the disease is cancer.