Collectively, these findings indicate a rather intriguing specificity in how genes are epigenetically reprogrammed in HCC patients: an enrichment in hypermethylated and upregulated genes (for those corresponding to the Alb-R26Met model) versus an enrichment in hypomethylated and downregulated genes (for those corresponding to the HBxtg model). Here, ALB is linked to hepatocellular carcinoma.