Several of them are well-known oncogenes, such as Grb10, Map3k6, Jun, RelB, Met, Ptk7, as well as NF-KB2, Srd5a2, which have been functionally validated in this study together with others poorly investigated so far: Scn8a, Actn1, Neurl1b. Results from our functional assays in Alb-R26Met HCC cells demonstrate how downregulating each individual oncogene reduces, but not abolishes, cell tumorigenic properties. Here, ACTN1 is linked to hepatocellular carcinoma.