For the several genes found overexpressed and with hypermethylated CGIs in the H+E+ patient subset, such as WT1, DLK1, TP73, EEF1A2, IGF1R, DKK1, SPOCK1, ITPKA, HOXA3, NOX4, FZD10, VASH2, GATA2, SOX8, their upregulation in HCC samples is coherent with their reported function as oncogenes in cancer. This evidence concerns the gene SPOCK1 and cancer.