LGR5 and gastric adenocarcinoma: We observed that LGR5 induced the formation of vast number of lamellipodia and filopodia in gastric adenocarcinoma cells, corroborating its role in metastasis of gastric adenocarcinoma It was found that LGR5 indeed promoted formation of vast lamellipodia and filopodia as well as actin rearrangement.