To investigate if LGR5 regulates the gastric adenocarcinoma cell proliferation through Wnt signaling, we used Wnt inhibitor or activator to regulate the Wnt pathway and detected the functional relationship between LGR5 and the Wnt/β-catenin pathway in BGC823 and SGC7901 cells. The gene discussed is LGR5; the disease is gastric adenocarcinoma.