Based on the findings that differential regulation of Wnt signaling pathway affected LGR5-induced proliferation and migration in gastric adenocarcinoma cells, we further explored the effect of LGR5 on the localization of β-catenin and the downstream effectors of Wnt signaling pathway in both gastric adenocarcinoma cells. The gene discussed is LGR5; the disease is gastric adenocarcinoma.