CASP3 and acute myeloid leukemia: We also investigated pretreatment of AML cells KG-1 and MV-4-11 with ixazomib for 18 hours and confirmed that this brief exposure to a FOXM1 inhibitor was sufficient to induce sensitization to subsequent treatment with cytarabine, as assessed by caspase-3 cleavage (Figure 7D) and by annexin staining (Figure 7, E and F).