TNFRSF11B and type 2 diabetes mellitus: Poor glycemic control may influence the levels and activity of cytokines active on bone turnover, some studies demonstrated that OPG is increased in T2DM and T1DM patients regardless to their glycemic control [49, 50], this finding is controversial as another study shows a reduction in OPG in T1DM patients [51], here we do not find any significant increase in OPG regardless to glycemic control.