GJA1 encodes for connexin-43, a gap junction protein whose expression in breast cancer cells has been implicated in pulmonary metastasis (Elzarrad et al., 2008), consistent with observed lung metastasis in both patients from which the ESR1-e6>YAP1 and ESR1-e6>PCDH11X fusions were identified. Here, ESR1 is linked to breast cancer.