A single TCGA case displayed evidence for three ESR1 gene fusions: (1) a PCR-validated ESR1-e6 fused in frame to C-terminal sequences from AKAP12 (ESR1-e6>AKAP12) (Figure S1); (2) a PCR-validated in-frame ESR1-e7 fusion involving the entire coding sequence of POLH, a DNA polymerase in the xeroderma pigmentosum gene family (ESR1-e7>POLH), and (3) an out-of-frame ESR1-e4>CCDC170 fusion. This evidence concerns the gene AKAP12 and xeroderma pigmentosum.