INS and type 1 diabetes mellitus: Therefore, the aim of this study was to utilize a detection method using HLA-A2 class I tetramers specific for the epitopes PPI15-24 (auto-reactive), INS-DRIP1-9 (neo-reactive) and CMV-pp65495-503 (virus-reactive) to detect peptide-specific CD8 T-cells in mass cytometry and to assess whether these specific CD8 T-cells in T1D patients display a distinct phenotype.