ESR1 and cancer: For the 1403 DEGs in ER+HER2-BC, we identified many significant and cancer-related pathways that were not found in TNBC including Notch Signaling, FAK Signaling, ILK Signaling, HER2- Signaling in Breast Cancer, PAK Signaling, Paxillin Signaling, and Wnt/Ca+ Signaling, ERK/MAPK Signaling, and PCP Signaling (Fig 4C).