There are 1403 DEGs uniquely identified in ER+HER2-BC including the top 10 up-regulated genes: CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes: FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (S5 Table). The gene discussed is XDH; the disease is breast cancer.