INS and diabetes mellitus: Alloxan is a widely used drug to induce 1 DM type in experimental models, for destroying the pancreatic beta cells, causing alterations in glycemic homeostasis in the animals (e.g., hyperglycemia, reduction of hepatic glycogen and reduced circulating insulin).3,5,12,13 Furthermore, the induction of DM by Alloxan provides an experimental background for investigating the effects of physical training as a therapeutic intervention for this disease.3,5,12,13