Thys therapy increases several metabolic parameters, such as muscular glycogen during activity, lipid contribution to energy metabolism, number and size of muscular mitochondria, insulin sensitivity and important enzymes responsible for lipid mobilization and oxidation.7-9 In addition, physical exercise contributes to peripheral amino acid and glucose uptake, helps preserve muscular glycogen storage, and reduces protein catabolism typical of type 1 diabetes.2,10,11. The gene discussed is INS; the disease is type 1 diabetes mellitus.