Roughly 40.6 thousand cases of acquired immunodeficiency syndrome (AIDS) have been reported annually in Brazil over the last five years.(1) AIDS is caused by the human immunodeficiency virus (HIV) and is characterized by reduced CD4 T-cell counts and increased patient susceptibility to opportunistic infections due to impaired immune response.(2) Specific oral manifestations play a significant role in diagnosis and monitoring of disease progression.(3). This evidence concerns the gene CD4 and AIDS.