Also in a small study, 171 patients with acute HF, Noveanu and coworkers reported that predischarge levels of BNP and NT-proBNP reliably predicted one-year mortality (AUC 0.78 and 0.77 respectively); however, prediction of one-year HF readmission was poor for both markers [7]. This evidence concerns the gene NPPB and hydrops fetalis.