MAPT and Alzheimer disease: In this regard, compared with wild-type mice, transgenic mice designed to develop accumulation of amyloid β-peptide and selective hyperphosphorylated tau pathology in hippocampal CA1 neurons (3 × TgAD mice) showed age-related elevation of L-type Ca2+ channel current density in these specific neurons, suggesting a contribution of VOCCs to the selective vulnerability of CA1 neurons to tau pathology, and a possible role to neuronal degeneration in AD patients [59].