Besides, there has been shown to be a Ca2+-dependent dysregulation of the high affinity Ca2+ transporter plasma membrane Ca2+-ATPase in AD brains and its inhibition by the amyloid-β peptide (generated by aberrant cleavage of APP) and tau, the main components of the two major pathological hallmarks of AD [25–27]. The gene discussed is PPIB; the disease is Alzheimer disease.