Despite the different mechanisms of action in reducing PKM2 activity, each study showed that decreased PKM2 activity via post-translational modification supported the Warburg Effect phenotype and increased tumor proliferation (Table 1; Hitosugi et al., 2009; Anastasiou et al., 2011; Lv et al., 2011; Yu et al., 2013). This evidence concerns the gene PKM and neoplasm.