Consistent with increased expression in promoting tumor growth, phosphorylation of PGAM1 at Y26 by FGFR1 and other tyrosine kinases increases the binding of the cofactor 2,3-BPG to enhance PGAM1 activity and subsequently increasing tumor growth (Figure 1; Hitosugi et al., 2013). This evidence concerns the gene FGFR1 and neoplasm.