While it may seem counterintuitive for cancer to display decreased PKM2 activity in the Warburg Effect, it has been proposed that this decrease in PKM2 activity promotes an increase in flux of glycolytic intermediates to biosynthetic pathways including PPP for nucleotide biosynthesis as well as serine biosynthesis pathways (Eigenbrodt and Glossmann, 1980; Anastasiou et al., 2011; Lunt and Vander Heiden, 2011; Lunt et al., 2015). This evidence concerns the gene PKM and cancer.