Fan et al. showed that tyrosine phosphorylation of LDHA is an additional approach by which oncogenes upregulate LDHA activity to promote tumor growth in non-small cell lung carcinoma (NSCLC) H1299 cell line xenograft model, where phosphorylation of LDHA at Y10 promotes the formation of the highly active tetrameric conformation of LDHA while phosphorylation of Y83 promotes increased binding affinity of LDHA for the cofactor NADH (Figure 1; Fan et al., 2011). This evidence concerns the gene LDHA and non-small cell lung carcinoma.