Some paraspeckle proteins, such as TDP-13, FUS, EWS, TAF15, HNRNPA1, SS18L1, and SFPQ have been associated with neuro-degenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (Svetoni et al., 2016). Here, HNRNPA1 is linked to amyotrophic lateral sclerosis.