VEGFA and neoplasm: HIF-1α, through the activation of the downstream target gene VEGF and erythropoietin, EPO, GLUT1,3, and p53 affects the angiogenesis, erythropoiesis, sugar metabolism, cell apoptosis and epithelial mesenchymal activity of tumor and surrounding tissues (6), or regulation of enzymatic activity to reduce the level of reactive oxygen species, ROS (7) to promote the development, invasion and metastasis of tumor.