Studies suggest that TAM induces a variety of growth factors such as vascular endothelial growth factor (VEGF) and transforming growth factor -β(TGF -β), to promote extracellular matrix degradation, mediate immune escape, promote blood and lymphatic vessels generation and promote tumor occurrence, development, invasion and metastasis; all this results in poor prognosis (3). The gene discussed is VEGFA; the disease is neoplasm.