Balgkouranidou et al also studied RASSF1A methylation, along with APC methylation, in 73 operable gastric cancer patients of stage I-III and did not find a significant correlation with RASSF1A promoter methylation and clinical outcome; but showed that the group with pre-operative APC promoter methylation had a higher incidence of death (HR 4.6, p = 0.008). Here, APC is linked to gastric cancer.