ABCB1 and non-small cell lung carcinoma: Hypoxia (≤2% O2) can induce multidrug resistance (e.g., to cisplatin, carboplatin, paclitaxel, and gemcitabine) in NSCLC via upregulation of ABCB1 and EGF-like domain 7, an endothelial secreted factor that regulates vascular tube formation (89).