✓NOTCH1 gain-of function/loss of NUMB mutations: sensitive✓↓ Tumor formation in H1299 stem-like cells expressing ↑ NOTCH 2/4, HES1, HEY1 resistant to cisplatin/docetaxel, rescued by N1/2 ICD (not N3 ICD) in sphere formation✓↓ NOTCH1-mediated ↑ IGFR-1-mediated AKT-1 expression by ↓ PTEN under hypoxia and ↑ apoptosis under hypoxia✓↓ NOTCH3: ↓ growth and ↑ tumor apoptosis via ↓ p-ERK, p-BCL-2, BCL-Xl and ↑ BIM, BAX, p-BAD proteins. Here, HES1 is linked to neoplasm.