Aberrantly high TP53 expression before the start of treatment is associated with strong histopathological responses (e.g., necrosis and fibrosis) to cisplatin, and it has been reported that in only 13% of the cases, there is an alteration of TP53 expression levels before and after cisplatin treatment in stage IIIA NSCLC (93). This evidence concerns the gene TP53 and non-small cell lung carcinoma.