✓↑ P-c-Jun, ↑ AP-1-regulated miR-451, ↓ MDR-1✓Cisplatin-treated cells with ↑ drug transporters: sensitive✓↓ Viability of cisplatin-resistant CD133+ cells✓Gefitinib-resistant cells: ↑ NOTCH1, HES1, and cyclin D1, ↓ P21 WAF1/CIP1✓GSI + cisplatin/docetaxel/gefitinib: in vivo chemosensitization, ↑ G2/M arrest, ↓ proliferation, ↑ apoptosis✓GSI + Pterostilbene: ↓ tumor growth in vivo, ↓ pterostilbene-mediated ↑NICD, HES1 and ↓ PI3K/AKT, cyclin D1, survivin, DNA-PK, P-mTOR, P-S6 ribosomal protein. The gene discussed is HES1; the disease is neoplasm.