PIK3D and IGFR1 expression levels were significant negatively correlated to miR‐99a‐5p in HNSCC (PIK3D: r = −0.318, P < 0.001; IGFR1: r = −0.118, P = 0.005), while PDGFRB and MTOR were mildly negatively correlated with miR‐99a‐5p (PDGFRB: r = −0.036, P = 0.393; MTOR: r = −0.012, P = 0.774; Fig. 15). Here, MTOR is linked to head and neck squamous cell carcinoma.