Since there has been no systematic appraisal of the findings regarding the metabolic role of VEGFs to date, we aimed to systematically review and quantify all the available data on the expression of VEGF-A, VEGF-B, VEGF-C, VEGF-D and PIFG in adults, adolescents and children with metabolic syndrome or its components. This evidence concerns the gene VEGFB and metabolic syndrome.