INS and obesity due to melanocortin 4 receptor deficiency: Our finding of a correlation between VEGF-B and obesity corresponds to the findings observed by Robciuc et al. They observed that increased VEGF-B expression in the adipose tissue of a Vegfb transgenic mouse model increased capillary density, tissue perfusion, and insulin supply by the binding of VEGF-B to VEGFR1, which then activates the VEGF-A/VEGFR2 pathway [11].