The metabolic roles of VEGF-C, VEGF-D, and a VEGF discovered in human placenta called placental growth factor (PIGF) have not been studied as extensively as those of VEGF-A and VEGF-B, but the evidence suggests that circulating VEGF-C is significantly increased in obese as compared to lean individuals, whereas both circulating and adipose tissue levels of VEGF-D seem to be significantly lower in obese patients as compared to lean individuals, showing a positive correlation with the degree of insulin resistance [9, 10]. This evidence concerns the gene VEGFC and Insulin resistance.