Instead, here we applied an established practice common to the study of hereditary diseases (Hateboer et al., 2000; Tartaglia et al., 2002; Aartsma-Rus et al., 2006; Mori-Yoshimura et al., 2012), and focused specifically on correlations between mutations in regions encoding protein domains or other regions of the NF1 gene and the OPG phenotype in patients with neurofibromatosis type I. The gene discussed is NF1; the disease is neurofibromatosis type 1.