DICER1 and arthritic joint disease: In this regard, our observations indicating that (i) Dicer1-deficient mice exhibit worsened symptoms following experimental (upon K/BxN serum transfer) arthritis induction and (ii) that FLS cultivated from biopsies harvested in RA patients exhibit reduced DICER1 expression (7) pinpoint to a potential involvement of non-canonical, miRNA-independent activities of DICER1 in joint inflammation.