These observations, along with ours showing that reduced expression of DICER1 in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients is associated with no more than a modest reduction of miRNA production (7), strongly suggest that other roles, besides miRNAs maturation, might be attributed to DICER1. Here, DICER1 is linked to rheumatoid arthritis.