In inflammation, STAT1 activates the ANRIL locus in vascular endothelial cells has been reported; CAD-associated ANRIL SNP rs10757278, located in a known downstream enhancer region, disrupts the STAT1 binding site and modulates IFN-γ induced ANRIL expression via stimulation (43). The gene discussed is CDKN2B-AS1; the disease is coronary artery disorder.