CDKN2A and type 2 diabetes mellitus: On the other hand, a T2D risk-SNP in ANRIL exon 2 (group C in Table 1) was associated with reduced ANRIL expression, again with no change in p14ARF, p15INK4B, or p16INK4A expression (14, 48); however, these studies were carried out in blood rather than islets.