ANRIL miRNA regulation has been implicated in cancers as well, including mechanisms involving let-7a and miR-125a in nasopharyngeal and oral carcinoma (56, 88, 101), miR-99a/miR-449a in gastric cancer (22), miR-122-5p in hepatocellular carcinoma (54), miR-186 in cervical cancer (91), and miR-199a in breast cancer (57), miR-34a in glioma (55), and miR-323 in pediatric medulloblastoma (102). Here, CDKN2B-AS1 is linked to central nervous system cancer.