ANRIL is implicated in many malignancies, including cancers of the bladder (77), ovary (78, 79), lung (38, 58, 80–82), liver (40, 54, 83), stomach (22), breast (57, 84, 85), esophagus (86), nasopharyngeal cavity (39, 87, 88), thyroid (89), bone (90), cervix (91), colon (92), prostate (21, 56), glioma (55), and others (76). The gene discussed is CDKN2B-AS1; the disease is central nervous system cancer.