Intriguingly, abundance of ANRIL in circulating plasma was positively correlated with in-stent restenosis (53), but in PBMCs harvested at the time of angioplasty/reperfusion, ANRIL levels were lower in subjects with myocardial infarction, but higher in subjects with older age, diabetes, hypertension. This evidence concerns the gene CDKN2B-AS1 and hypertensive disorder.