NR1H4 and mental disorder: However, recent genetic studies linked FXR family to schizophrenia, bipolar disorders, and mood regulation, indicating their wider role in adult-onset mental disorders (Bowden et al., 2008; Fromer et al., 2014; Purcell et al., 2014; Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014; Takata et al., 2017).