LGALS1 and neoplasm: In the subgroup of tumor type, it’s observed that high Gal-1 expression was correlated with poor OS in digestive cancers without heterogeneity (HR = 1.94, 95% CI 1.64–2.30, P < 0.001; fixed-effects model; I2 = 20.1%, P = 0.276) (Fig. 4a) and in not digestive cancers with obvious heterogeneity (HR = 1.61, 95% CI 1.33–1.94, P < 0.001; random-effects model; I2 = 42.5%, P = 0.066) (Fig. 4b).