LGALS1 and neoplasm: At present, it has been clarified by some clinical studies that the expression of Gal-1 has close association with metastasis, recurrence and bad tumor prognosis, which includes cholangiocarcinoma [5], gastric cancer [6–8], gingival squamous cell carcinoma [9], hepatocellular cancer [10–12], renal cell cancer [13], head and neck squamous cell carcinomas [14], ovarian cancer [15, 16], non-small cell lung cancer [17, 18], classic Hodgkin lymphoma [19], laryngeal squamous cell carcinomas [20], glioblastoma [21, 22] and so on.