After adjustment with the trim-and-fill method, the pooled association between Gal-1 expression and OS in tumor patients was also significant (fixed-effects model: HR = 1.49, 95% CI 1.36–1.64, P < 0.001; random model: HR = 1.53, 95% CI 1.30–1.80, P < 0.001), and with significant heterogeneity (P < 0.001). The gene discussed is GAL; the disease is neoplasm.