PGRMC1 and its homolog PGRMC2 are involved in regulating entry into the G1 stage of the cell cycle.(43) In addition, PGRMC1 regulates spindle microtubule stability during mitosis in ovarian cancer cells and interacts with beta-tubulin.(44) PGRMC1 also participates in late events of both mammalian mitosis and oocyte meiosis.(45) Thus, PGRMC1 is thought to activate cell proliferation by regulating several steps during the cell cycle in various cell types. The gene discussed is PGRMC1; the disease is ovarian cancer.